When trying to debug valid client side script in a complex scenario (script inside a Content block inside a page using a Master Page, with a ScriptManagerProxy), I get the following error when trying to debug client side script:
The breakpoint will not currently be hit. This location could not be mapped to client side script
Odd thing is, if I copy and paste parts of the page or project to a new Web Site Project, debugging seems to work most of the times. It seems to be the combination of things in this project that makes it fail.